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Tuesday, November 10, 2020 | History

2 edition of Bioassay of n-nitrosodiphenylamine for possible carcinogenicity. found in the catalog.

Bioassay of n-nitrosodiphenylamine for possible carcinogenicity.

National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

Bioassay of n-nitrosodiphenylamine for possible carcinogenicity.

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  • 20 Currently reading

Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Testing Program in Bethesda, Md .
Written in English

    Subjects:
  • Carcinogens.,
  • Nitrosoamines -- Toxicology.

  • Edition Notes

    SeriesCarcinogenesis technical report series ; no. 164, DHEW publication ; no. (NIH) 79-1720, DHEW publication -- no. (NIH) 79-1720.
    The Physical Object
    Paginationx, 106 p. :
    Number of Pages106
    ID Numbers
    Open LibraryOL18014553M

    (3) The mileage on a fuel economy data vehicle must be, to the extent possible, accumulated according to (a)(2). (4) Each fuel economy data vehicle must meet the same exhaust emission standards as certification vehicles of the respective engine-system combination during the test in which the city fuel economy test results are generated. N-Nitrosodimethylamine Hazard Summary Individuals may be exposed to low levels of N-nitrosodimethylamine in occupational settings, through the. POTENTIAL INDUSTRIAL CARCINOGENS AND MUTAGENS Studies in Environmental Science Volume 1 Atmospheric Pollution Proceedings of the 13th International Colloquium, held in Paris, April , edited by e. EXPERIMENTAL TOXICOLOGY The Basic Issues Second Edition EXPERZMENTAL TOXZCOLOGY The Basic Issues Second Edition Edited by Diana Anderson The British Industrial Biological Research Association, Carshalton, Surrey D. M. Conning The British Nutrition Foundat ion, London A catalogue record for this book is available from the British Library.

    Chapter 33 - Toxicology. INTRODUCTION Ellen K. Silbergeld Toxicology is the study of poisons, or, more comprehensively, the identification and quantification of adverse outcomes associated with exposures to physical agents, chemical substances and other conditions. As such, toxicology draws upon most of the basic biological sciences, medical disciplines, epidemiology and some .


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Bioassay of n-nitrosodiphenylamine for possible carcinogenicity. by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Download PDF EPUB FB2

Get this from a library. Bioassay of n-nitrosodiphenylamine for possible carcinogenicity. [National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.].

N-NITROSODIPHENYLAMINE. FOR POSSIBLE CARCINOGENICITY. Careinogenesis Testing Program. Division of Cancer Cause and Prevention National Cancer Institute National Institutes of Health Bethesda, Maryland U.

DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE Public Health Service National Institutes of Health NIH Publication No. N-Nitrosodiphenylamine (NDFA) has been determined using thin layer (Ref. ), liquid (Ref. ), and gas (Ref. ) chromatographic techniques. Methods that utilize gas chromatography are somewhat tedious because a cleanup procedure, to separate NDFA from diphenylamine (DFA), must be performed prior to GC no.: N-Nitrosodiphenylamine may be ignited by heat, sparks, or flames; burning with a flare-like effect and the possible production of irritating or poisonous gases.

Fires involving N-nitrosodiphenylamine may be extinguished with dry chemical, sand, water spray, fog, or foam. For a massive fire, use unmanned hose holders. Although EPA has classified n-nitrosodiphenylamine as a probable carcinogen, the animal data are limited.

Other public health agencies have concluded that no evaluation of n-nitrosodiphenylamine's carcinogenicity in people is currently. Summary: n-Nitrosodiphenylamine is an industrial compound. It is an orange-brown or yellow solid that has been produced since n-Nitrosodiphenylamine is used to make rubber products such as tires or to make other chemicals.

In the early s, most U.S. rubber manufacturers replaced it with more efficient chemicals. Author(s): Frederick Cancer Research Center.; National Institutes of Health (U.S.); Carcinogenesis Testing Program (U.S.) Title(s): Bioassay of n. N-Nitrosodibutylamine was the principal nitrosamine found Mean total volatile N-nitrosamine levels for baseline and compliance samples were and ppb, resp.

The pacifier lots sampled after January 1, had a significant decrease in contamination levels, indicating that at least 98% of the market share is in compliance with the. N-Nitrosodiphenylamine (NDFA) has been determined using thin layer (Ref. ), liquid (Ref. ), and gas (Ref. ) chromatographic techniques.

Methods that utilize gas chromatography are somewhat tedious because a cleanup procedure, to separate NDFA from diphenylamine (DFA), must be performed prior to GC analysis.

Explore information about Air pollutants, contaminants and studies being done. ALS Environmental may or may not test for N-Nitrosodiphenylamine (CAS # ). Information is subject to change; please contact us for the latest available analytes for which we test.

ALS Environmental does not sell chemicals, but offers analytical lab testing to determine the presence of various elements and chemical compounds. N-NITROSODIPHENYLAMINE may be sensitive to moisture at elevated temperatures in strongly acidic solutions.

May react vigorously with oxidizing agents. OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for.

Bioassay of N- Nitrosodiphenylamine for Possible Carcinogenicity. NCI Carcinogenesis Tech Rep Ser No (also publ. as NIH and NTIS PB ). 56 Section 10 NIOSH (National Institute of Occupational Safety and Health). Further studies in mammals are required to determine if this potential is expressed as heritable genetic change or as carcinogenicity.

It must be stressed that meaningful evaluations are dependent on a group of assays in a screening phase because no single assay can perform the safety evaluation function by: 4. National Cancer Institute () Bioassay of N-Nitrosodiphenylamine for Possible Carcinogenicity (Tech.

Rep. Ser. ; DHEW Publ. (NIH) ), US Government Printing Office, Washington, by: 5. NIH Publ No 79– () Bioassay of N-nitrosodiphenylamine for possible carcinogenicity. Natl Cancer Inst, Bethesda, Maryland Google Scholar NIH Publ No 79– () Bioassay of p-quinone dioxime for possible by: 1.

N-Nitrosodiphenylamine is an orange-brown or yellow solid. It evaporates slowly to the air and can attach to dust particles and travel with the wind.

It can dissolve in water and attach to soil. It breaks down to other substances, but we do not know whether these substances are harmful to humans, We have not found N-nitrosodiphenylamine in. Diphenylamine + N-Nitrosodiphenylamine ALS Environmental may or may not test for Diphenylamine + N-Nitrosodiphenylamine (CAS # CASID).

Information is subject to change; please contact us for the latest available analytes for which we test. In silico methods for predicting mutagenicity and rodent carcinogenicity based on chemical structural features, along with current mutagenicity and.

Two carcinogens (5-chloro-o-toluidine, 1,1,2,2-tetrachloroethane) may have a genotoxic element to their carcinogenicity and may have been expected to. Editor's note: Some chemicals in this database contain more information than others due to the original reason this information was collected and how the compilation was accomplished.

While working with material safety data sheets (MSDS), I found that manufacturers sometimes used obscure names for constituent chemicals and I didn't always have a good idea of what I was.

DATE: SUBJECT: FROM: TO: December 2, Background Document: Resource Conservation and Recovery Act Subtitle C VotAtt-t- J/£lA-Vj.^/H X^-^ Angela'WTlkes, Publications Officer Office of Solid Waste (WH) EPA Regional and Headquarters Librarians Background Documents "Listing of Hazardous Wastes (Section Parts.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. Ingestion: Do not eat, drink, or smoke during work. Rinse mouth. Refer for medical attention. Chem Pharm Bull (Tokyo).

Oct;30(10) Reduction of N-nitrosodiphenylamine to the corresponding hydrazine by guinea pig liver by: 1. N-Nitrosodiphenylamine [] p-Nitrosodiphenylamine [] N-Nitrosofolic acid [] This knowledge allows a more sophisticated interpretation of the results of a carcinogenicity bioassay.

Research towards a better understanding of the mechanisms of action of carcinogenicity is encouraged because it may lead to an altered. A scheme for ranking the quantitative activity of chemical carcinogens is described. This activity scheme uses as its base, dose potency measured as TD 50, the chronic dose rate that actuarially halves the adjusted percentage of tumor-free animals at the end of the study (Gold et al., Perspect., 67, –, ).Cited by: Presented below are water quality standards that are in effect for Clean It is the goal of these water quality standards, wherever possible, that all surface N-Nitrosodiphenylamine E+OO B,C E+OO B,C 65FR 65FR Find N-Nitrosodiphenylamine at now.

Great deals on chemicals and chemical supplies.5/5(7). The aim of the present study was to assess the carcinogenicity of daminozide alone and in combination with l,l-dimethylhydrazine (UDMH), its major contaminant, in a novel medium-term bioassay in Fischer rats, the diethylnitrosamine-hepatectomy model.

Rats were given diethylnitrosamine (DEN) at mg/kg body weight intraperitoneally and. Full text of "Casarett and Doull's toxicology: the basic science of poisons" See other formats.

Full text of "Monthly catalog of United States government publications" See other formats. While limitations exist in the toxicological database for chloroxylenol, substantial data indicate lack of genotoxicity, no evidence of carcinogenicity, and low systemic toxicity.

Data from Momma et al. () and Noda et al (), as well as Siglin et al. (), were used in this assessment to develop NOAELs for chronic toxicity including. In a cancer bioassay, male and female animals from two species (usually mice and rats) are exposed for most of their lives to a range of levels (doses) of the chemical.

This approach is intended to maximize the likelihood of detecting cancer-causing chemicals. The Guam Water Quality Standards were updated in N-nitrosodiphenylamine.

Tetrachloroethylene. These criteria are based upon carcinogenicity of 10 (-6) risk. N-Nitrosodiphenylamine Thiophenol (Benzenethiol) N-Nitrosodipropylamine Toluene Diisocyanate N-Nitrosomethylethylamine o-Toluidine N-Nitrosomorpholine Trimethyl Phosphate N-Nitrosopiperidine Tri-p-tolyl Phosphate N-Nitrosopyrrolidine Tris(2,3.

Halobenzoquinones (HBQs), a new class of disinfection byproducts (DBPs), occur widely in treated drinking water and recreational water. The main concern regarding human exposure to DBPs stems from epidemiological studies that have consistently linked the consumption of chlorinated drinking water with an increased risk of developing bladder by: Halobenzoquinones (HBQs) are a structurally diverse class of water disinfection byproducts.

Here, we report a systematic study on the effects of isomeric structure and the type and number of halogen substitutions of HBQs on their cytotoxicity, formation of reactive oxygen species (ROS), and genotoxicity. Dynamic responses and IC50 histograms were obtained using real Cited by: Included in this book was a review of the use of stormwater, treated municipal wastewater and irrigation return flows to recharge groundwater for eventual use as a drinking water supply.

The following is a summary from that book, describing these potential human health risks. Various chemical and bacteriological health risks were examined. Since when trihalomethanes (THMs) were first reported as disinfection by-products (DBPs) in drinking water, there has been an enormous research effort directed at understanding how DBPs are formed in the chlorination or chloramination of drinking water, how these chlorination DBPs can be minimized and whether they pose a public health risk, mainly.

Ozonation of Para-Substituted Phenolic Compounds Yields p-Benzoquinones, Other Cyclic α,β-Unsaturated Ketones, and Substituted CatecholsCited by:. The act seeks to achieve this goal by implementing four national policies and calling for states to implement programs which meet minimum federal standards.

The four national policies under the CZMA are: 1. To preserve, protect and develop, and where possible to restore and enhance the coastal zone (CZMA §[1], 16 USC §[1]) 2.Anthropogenic contaminants in water can impose risks to reproductive health.

Most of these compounds are known to be endocrine disrupting chemicals (EDCs). EDCs can impact the endocrine system and subsequently impair the development and fertility of non-human animals and humans. The source of chemical contamination in water is diverse, originating from Author: Andressa Gonsioroski, Vasiliki E.

Mourikes, Jodi A. Flaws.For the reasons set out in the preamble, ti chapter I of the Code of Federal Regulations, is amended as follows: PART —GUIDELINES ESTABLISHING TEST PROCEDURES FOR THE ANALYSIS OF POLLUTANTS 1.

The authority citation for Part continues to read as follows: Authority: Secs.(h),and (a) Pub. L.91 Stat.et seq. .